| Methylation is a critical biological process involved in DNA repair and the production of beneficial compounds in the body such as SAMe and methionine. Unhealthy nutrition and lifestyle choices can dampen methylation, but supplementing with Trimethylglycine (TMG) can help facilitate methylation. TMG is a methyl donor, meaning that it carries and donates methyl molecules to assist this essential chemical process in the body.1 Methyl donation is also vital to maintaining proper liver function. TMG is also involved in detoxification and cellular reproduction. Research indicates that supplementing with TMG also supports healthy homocysteine levels.2,3,4 The body uses the methyl donation function of TMG to convert homocysteine to methionine, a beneficial amino acid. Elevated homocysteine levels have been linked to a higher risk of heart attack, stroke, peripheral arterial disease, bone fractures and Alzheimer’s disease. A simple blood test is available to measure your homocysteine level and we recommend discussing this with your healthcare provider. Reducing red meat intake while increasing plant-based foods can also help lower elevated homocysteine levels.5 TMG also helps support healthy kidney function due to its role in the manufacture of carnitine, which has been studied for its effect on protecting the kidneys from oxidative stress.6,7
Supplementation with TMG: - Maintains proper cell function
- Supports liver health
- Promotes a healthy cardiovascular system
- May reduce homocysteine levels
Dosage: Take (1)-(2) tablets twice daily, preferably with meals. Ray & Terry’s TMG contains 100 tablets per bottle. | Supplement Facts | | Serving Size: 1 Tablet |
| | Amount Per Serving | % Daily Value |
| Trimethylglycine (TMG) (Betaine Anhydrous)
| 1g (1,000 mg) | * |
| *% Daily Value Not Established |
| Other Ingredients: Cellulose, Stearic Acid (vegetable source),Vegetable Coating, Croscarmellose Sodium and Magnesium Stearate (vegetable source).
| Methylation is a normal biological process that occurs in healthy human bodies every minute of every day. Methylation is an important step in the conversion of homocysteine, a damaging amino acid, into the biologically safe and beneficial amino acid, methionine. In addition, methylation is required for DNA repair, as well as for the production of SAMe, which helps maintain healthy joint tissue. Methylation can be inhibited by poor or inadequate diet and unhealthy lifestyle practices. TMG (Trimethylglycine) has been shown to be a safe and effective methyl donor for the facilitation of methylation processes. TMG supplementation has been shown in clinical and non-clinical studies to support a healthy homocysteine level, which in turn supports healthy cardiovascular function. |
References: - Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].
- Schwab U, Törrönen A, Meririnne E, Saarinen M, Alfthan G, Aro A, Uusitupa M. "Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans." J Nutr. 2006 Jan;136(1):34-8.
- Olthof MR, Verhoef P. "Effects of betaine intake on plasma homocysteine concentrations and consequences for health." Curr Drug Metab. 2005 Feb;6(1):15-22.
- Schwab U, Törrönen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. "Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects." Am J Clin Nutr. 2002 Nov;76(5):961-7.
- Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
- Chambers ST. "Betaines: their significance for bacteria and the renal tract." Clin Sci 1995;88:25-7.
- Ustundag S, Sen S, Yalcin O, Ciftci S, Demirkan B, Ture M. "L-Carnitine ameliorates glycerol-induced myoglobinuric acute renal failure in rats." Ren Fail. 2009;31(2):124-33.
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