Other Ingredients: Rice Flour, Gelatin (capsule), Magnesium Stearate (vegetable source) and Silica.
GABA (gamma aminobutyric acid) is a non-essential amino acid found mainly in the human brain and eyes. It is considered an inhibitory neurotransmitter, which means it regulates brain and nerve cell activity by inhibiting the number of neurons firing in the brain. GABA is referred to as the "brain's natural calming agent". By inhibiting over-stimulation of the brain, GABA may help promote relaxation and ease nervous tension.
Dosage: To maintain mood, take (1) capsule once to twice daily. To assist in better sleep, take (1-2) capsules at bedtime.
Ray & Terry's GABA 500 mg contains 100 capsules per bottle.
Sleep patterns are affected by GABA levels and some people who take supplemental GABA get to sleep more quickly and enjoy a deeper sleep pattern.6 Research on mice lacking a particular GABA gene experienced disrupted or irregular sleeping patterns, and GABA was able to stabilize the sleep/wake states.7
People with GABA deficiencies often experience feelings of stress, restlessness and anxiety. Brain excitement is balanced by the inhibitory properties of GABA and increasing the amount of GABA in the system can help promote relaxation and ease anxiety.5 Because GABA is involved in endorphin production, the nutrient may also help promote a feeling of well-being.
- Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H."GABA and GABA receptors in the central nervous system and other organs." Int Rev Cytol. 2002;213:1-47.
- Ganguly K, Schinder AF, Wong ST, Poo M. "GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition." Cell. 2001 May 18;105(4):521-32.
- Haydar TF, Wang F, Schwartz ML, Rakic P. "Differential modulation of proliferation in the neocortical ventricular and subventricular zones." J Neurosci. 2000 Aug 1;20(15):5764-74.
- Ben-Ari Y. "Excitatory actions of gaba during development: the nature of the nurture." Nat Rev Neurosci. 2002 Sep;3(9):728-39.
- Foster AC, Kemp JA. "Glutamate- and GABA-based CNS therapeutics." Curr Opin Pharmacol. 2006 Feb;6(1):7-17. Epub 2005 Dec 22.
- Chung BY, Kilman VL, Keath JR, Pitman JL, Allada R. "The GABA(A) Receptor RDL Acts in Peptidergic PDF Neurons to Promote Sleep in Drosophila." Curr Biol. 2009 Feb 18.
- Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami KI, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T. "Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture." Proc Natl Acad Sci U S A. 2009 Feb 25.