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12-27-2012 Brain

Wednesday, December 19, 2012 3:58:17 PM America/New_York

Ray and Terry's Logo Thank you for your dedication and work. Your work and advice will assist me as I endeavor to live long enough to reap the benefits the scientific community offers mankind's future. -Donald, Moweaqua, IL
New Research Digest: Brain Function and Failing
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Dear Valued Customer,

Central Command.

Your brain directs activity in the rest of your body. When it malfunctions, you cannot enjoy life. You cannot maintain health.

Although we are working to reverse engineer the brain and may be able to rebuild the organ in the near future, we do not have full capability yet.

Perhaps that is why we worry so much about loss of memory, cognitive function, and sharpness.

Statistics

Click here to view movie

Video source: http://www.alz.org

» United States

  • Alzheimer's is the 7th leading cause of death in the US
  • One out of every eight people over 65 has the disease
  • For those over 85, one out of every two people is at risk for Alzheimer's

Alzheimer’s disease is the most common form of dementia. It causes problems with memory, behavior and thinking that worsen over time, eventually leading to death. Over 5 million people in the United States have the disease. There is no cure. Cases are expected to increase as the large boomer population grows older.

Alzheimers.gov is the US government's free information resource about Alzheimer's disease and related dementias. The site offers tips to plan ahead, caregiver resources, treatment options and more.

The estimated cost of treating Alzheimer's disease in the United States in 2012 is estimated to be $200 billion.

» Worldwide

As of 2010, there were an estimated 35.6 million people with dementia worldwide. This number will nearly double every 20 years, to an estimated 65.7 million in 2030, and 115.4 million in 2050.

Much of the increase will be in developing countries. Already 58% of people with dementia live in developing countries, but by 2050 this will rise to 71%. The fastest growth in the elderly population is taking place in China, India, and their south Asian and western Pacific neighbors.

View the statistics report here.

 

Testing & Evaluation

lifestyles

Alzheimer’s is affected by a combination of genetic and environmental factors. At this time, there is no single genetic test or imaging technique to predict or detect AD.

Genetic Risk

There is a blood test for APOE-e4, the strongest risk gene for Alzheimer's. However, the test is mainly used in clinical trials to identify people at higher risk of developing Alzheimer's. The gene mutation indicates a greater risk, but it does not guarantee that an individual will develop the disease.

Familial Alzheimer’s

Testing also is available for genes that cause autosomal dominant Alzheimer's disease (ADAD) or "familial Alzheimer's," a rare form of Alzheimer's that accounts for less than 5 percent of all cases. ADAD runs strongly in families and tends to begin earlier in life.
These testing options should be discussed with a genetic counselor and/or complementary physician.

Physicians can evaluate a patient’s cognitive function after considering the results of mental and cognitive exams.

Mini-Cog Test

The Mini-Cog is a rapid screening test for Alzheimer's disease that takes only 3 to 5 minutes to administer. It is highly accurate. However, if you administer this test and suspect impairment, please do not reach any conclusions without consulting a medical professional.

mDNA Indicators

Thus far, research on mitochondrial DNA has not been able to isolate a specific common variant in individuals who develop the disease.

Brain Imaging Techniques

More recently, a variety of imaging techniques including MRI and positron emission tomography (PET) studies have shown characteristic changes in the brains of patients with AD. As imaging technology develops further, scientists hope to use it to predict and understand Alzheimer’s

 

Prevention

There is no guaranteed method of prevention. However, there are steps that you can take to preserve brain health that experts believe lower the risk of dementia and Alzheimer’s.

Alzheimer’s Avoidance: Seven Steps

The good news is, the steps that can help prevent Alzheimer’s are steps that will make you healthier in general. Good health will lead you to a good long life, and technology is going to give us even more ways to live better and longer.

Try this quick Memory Quiz to check yourself.

A combination of diet, exercise, stress relief, and mental activity can help delay the onset of Alzheimer’s.

There are drugs under development to treat Alzheimer’s and dementia. However, there are no existing cures or preventative medicines. Actively maintaining cognitive function through lifestyle is the only weapon we currently have against mental decline.

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Stay tuned for more special offers and resources!

To ensure you receive all special offers from Ray & Terry's, please add info@rayandterry.com to your address book or contacts list.

Best wishes for great health!

Ray & Terry's Longevity Products

 
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Research
Studies

Deficiency May Contribute to Alzheimer’s and Dementia

NCBI logoCould physicians be overlooking a major contributor (or cause) of Alzheimer’s and dementia, simply because nutrition is not their main focus? Research suggests that B-12 deficiency is related to cognitive decline and that it is an early sign. In fact, there is a possibility that counteracting the deficiency early could help reverse a serious slide.

Some of the signs of B-12 deficiency include: brain fog (trouble focusing), trouble walking, forgetfulness…

Link to Study (PDF)

Rusty Brain?

Wall Street Journal LogoDoes rust (literally) in the brain lead to Alzheimer’s? Research has shown Alzheimer’s and Parkinson’s disease both feature excess iron in the brain.

Increased Vitamin D may Reduce Alzheimer’s Risk

Oxford Press LogoPeople with higher intakes of vitamin D appear to have a significantly lower risk of Alzheimer’s, though not other dementias, according to a new study. A study follow up concluded that higher vitamin D dietary intake was associated with a lower risk of developing AD among older women. 

Genetic Link to Late Onset Alzheimer’s

NCBI logoA new study provides strong evidence that a genetic variant called IDE (insulin degrading enzyme) is a late-onset Alzheimer disease gene that affects risk of the disease.

Zinc Transporters Linked to Alzheimer’s

NCBI logoRecent research suggests that zinc contributes significantly to Alzheimer’s pathology, and manipulation of zinc transporters in AD brains may provide a novel therapeutic strategy.

Enzymes Studied to Restore Cognition

NCBI logoResearch has not yet found a way to remove or prevent the beta amyloid plaque build-up that is associated with Alzheimer’s diseased brain tissue. Other substances, such as phosphosdiesterases (a particular class of enzymes), have been shown to restore memory and cognitive deficits in animal models. These compounds have promise for AD treatment.

Compound Boosts Neurogenesis

Wiley logoEGCG, a compound found in green tea, crosses the blood-brain barrier and boosts cell production in key areas of the brain, enhancing memory and learning. This compound can be used to help improve brain function.

Vitamin E and Cognitive Health

GraphicA study comparing individuals with Alzheimer’s or Mild Cognitive Impairment to individuals without impaired cognitive function showed a link between lower levels of vitamin E in the blood and higher instances of cognitive disease. 

Games & Apps

Try a few brain games to boost your mental acuity. Here you can try a few of the games offered by Lumosity for free.

Luminosity logoLumosity is a fee-based service that provides brain training designed by neuroscientists.

PowerVocab logoPowerVocab is a free app that builds vocabulary as you play the game.

Braingle is a free site that offers games in all Braingleareas of brain training. It features an active community forum and user-generated content keeps the service feeling fresh.

Other apps such as chess games, word games, and math exercises all help strengthen mental power. Keeping the brain strong and healthy now is important to minimize loss of acuity later.

KurzweilAI.net Reports

How memory formation is triggered by stem cells

Old and new neuron cells get together to share the burden of pattern recognition. They store old memories, then bring them up to compare similarities and differences.

New insights into how the brain stores memories

Exactly how does long-term memory get updated? This new insight helps explain how the brain stores memories.

Neurons made from stem cells drive brain activity after transplantation

Researchers at Sanford-Burnham Medical Research Institute have found a way to stimulate stem cell-derived neurons to direct cognitive function after transplantation to an existing neural network.

A better brain implant: listening to single neurons

A thin, flexible electrode developed at the University of Michigan is 10 times smaller than the nearest competition and could make long-term measurements of neural activity practical.

How to detect microvesicles in the bloodstream to diagnose and monitor brain cancer

There’s a promising new solution for diagnosing glioblastoma brain cancer, which are deep in the brain and hard to test for.

New stem-cell-derived cells hold promise for Alzheimer’s, other brain diseases

UC Irvine researchers have created a new stem cell-derived cell type with unique promise for treating neurodegenerative diseases such as Alzheimer’s.

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Create a Mind

AnnouncementNo recent futurist has been more influential than Ray Kurzweil.

His provocative new book explores the most important science project since the Human Genome.

Drawing on the most recent neuroscience research, his own research and inventions in artificial intelligence, and compelling thought experiments, Ray describes his new theory of how the neocortex (the thinking part of the brain) work.

How to Create a Mind: The Secret of Human Thought Revealed is available now at Amazon.com and BN.com

Share Health

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ShareConnect Socially with Ray and Terry's

Healthy Trivia

TriviaHow much does the average human brain weigh?

a

1 pound

b

3 pounds

c

5 pounds

d

10 pounds

Click here for the answer

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References:

ACS Chem Neurosci. 2012 Nov 21;3(11):832-44. doi: 10.1021/cn3000907. Epub 2012 Oct 1.
Br Med J. 1956 December 15; 2(5006): 1394–1398.
Can Fam Physician. 1981 October; 27: 1474, 1476-[1477].
Cold Spring Harb Perspect Med. 2012 April; 2(4): a006213.
J Alzheimers Dis. 2010 January; 19(1): 363–372.
J Alzheimers Dis. Author manuscript; available in PMC 2011 April 19.
Molecular Nutrition & Food Research. 2012, DOI: 10.1002/mnfr.201200035
Neurobiol Aging. 2012 Oct;33(10):2282-90. Epub 2011 Dec 20.
Neurologist. Author manuscript; available in PMC 2011 March 10.
Neurology. 2010 February 9; 74(6): 480–486.
Neurology. 2012 April 3; 78(14): 1038–1042.
PLoS Genet. 2012 April; 8(4): e1002683.
TIME magazine, March 19, 2012, page 14.

0 Comments | Posted in Research Digest By Sarah Brangan

06-24-2012 Omega-3's

Thursday, September 20, 2012 1:28:18 PM America/New_York

Ray and Terry's Logo Thank you for your dedication and work. Your work and advice will assist me as I endeavor to live long enough to reap the benefits the scientific community offers mankind's future. -Donald, Moweaqua, IL
Research Digest: OMEGA-3s Edition
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Dear Valued Customer,

Most of us are aware that fish and omega-3s are healthy. But do you know why and how they work?

This special research digest edition amasses omega-3 information and fish findings.

Consumption of omega-6 fats (a fat found in abundance in soybean, corn, safflower and sunflower oils) has increased steadily in the United States since the early 1900s. The average citizen now consumes 25 grams of omega-6 inflammatory fats per day (vs. 7 grams just over 100 years ago). At the same time, incidence of disease such as heart disease, obesity, depression, cancer, and diabetes have risen sharply.

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Research Studies

Omega-3 fats have many beneficial health effects and there are myriad studies exploring these mechanisms.

Essential Fatty Acids

>> Weight

Omega-3s from fish oil boosted levels of adiponectin in overweight people; the hormone may help deter obesity and diabetes

A healthy diet that included omega-3 fats, plus plenty of beans and vegetables may help lessen the effects of, or even prevent, "metabolic syndrome." The omega-3s help support healthy blood pressure, cholesterol levels, and may even block fat cell formation.

>> Diabetes

Omega-3 may reduce risk of diabetes. A recent study indicated "omega-3 fatty acids play a role in metabolic processes with respects to blood sugar and fat processing; reducing the risk of developing type 2 diabetes."

>>Heart

Women's heart disease risk cut in half by fish. Heart disease is the number one cause of death in women. A recent study links moderate intake of fish to a 50 percent lower risk of heart disease.

Long term research has linked eating more fish and less saturated fat to improved cholesterol levels. Statin drugs did not appear to offer further benefits.

Omega-3 lessens stroke damage. There is growing evidence in animal studies that omega-3, particularly DHA, can reduce brain damages from injury and stroke. More research is needed to determine protective effect.

>> Brain

Fish makes for a stronger brain. According to a novel MRI study, "consuming baked or broiled fish promotes stronger neurons in the brain’s gray matter by making them larger and healthier." This "increases the brain’s resistance to Alzheimer’s disease and lowers risk for the disorder."

Maintaining the proper balance between omega-3  and omega-6 may help prevent Alzheimer’s disease. Also, reducing cholesterol intake and consuming antioxidants have a related effect. Overall, it appears that a healthy diet will preserve your mind. As stated in the following study, "the use of a diet with an appropriate ω-3/ω-6 PUFA ratio, rich in healthy oils, fish and antioxidants, such as flavonoids, but low in cholesterol-containing foods, can be a beneficial component in the clinical strategies of prevention of AD."

Omega-3 fatty acids have been linked with improved brain function. The mechanism was examined in a 2006 animal study. The omega-3s helped maintain higher levels of fluidity in the brain, thereby preserving memory and mental flexibility during aging. 

>> Mood

Research indicates that omega-3s reduce anxiety chemicals and inflammation in healthy young people. This study showed 20% reduction in anxiety and decreased cytokines from omega-3 intake.

Omega-3 intake appears to help relieve depression, mainly when another anxiety disorder is not involved.

>> Eyes

Omega-3 fats directly inhibit the cellular activity that contributes to retinopathy, according to a 2011 study led by scientists from Harvard Medical School. In this eye condition, which is responsible for the blindness associated with diabetes, the retinal vessels grow ‘sprouts’ which eventually interfere with eye function and cause blindness. During digestion, omega-3 breaks down into parts including a metabolite called 4-HDHA, which specifically inhibits this irregular blood vessel growth.

Omega-3s appear to slow the progression age-related macular degeneration (AMD) by a significant percentage. Inflammatory omega-6 fats (found primarily in heavy vegetable oils and fried foods) may increase the risk of AMD.

>> Bone

Omega-3's appear to reduce instance of osteoarthritis in an animal study (by 50%). One animal study has shown that the omega-3s in fish oil helped maintain bone and joint health.

Omega-3 fats may help reduce the physical damage caused by smoking. According to a study in 2011, "omega-3 PUFAs improved endothelial function and the elastic properties of the arterial tree in healthy smokers, with a parallel anti-inflammatory effect."

A meta-analysis suggested a link between high consumption of omega-3s and lower levels of homocysteine, although more research is needed to investigate the relationship.

Higher omega-3 intake and blood levels have been associated with a lower risk of breast cancer. In addition, the ratio between the less-desirable omega-6 fats and the healthy omega-3s also correlated with variations in the occurrence of breast cancer.

 

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In the Diet

Fishing for More than Omega-3

The benefits of salmon extend beyond its omega-3 content. Several recent studies have found that salmon contains small bioactive protein molecules (called bioactive peptides) that may provide special support for joint cartilage, insulin effectiveness, and control of inflammation in the digestive tract. Read the complete nutritional profile on salmon at the World’s Healthiest Foods.

Salmon is a perfect choice for summer barbeques. It has it all: grill-worthy and satisfying texture, healthy qualities, and recipe versatility.

Salmon Burnout?

There are many other fish and plant sources of omega-3 fats.
Flax seeds provide mainly DHA. They are easy to grind and add to yogurt, homemade granola, smoothies, or salads.

Here’s an easy shrimp salad that provides omega-3 nutrients and astaxanthin.

One of our favorites — Ray & Terry adapted their spicy Seafood Pozole recipe to yield 42% of its calories from protein.

The fragrant Omega-3 and Couscous has Mediterranean flair

Both the fish and the olives in Roasted Fish Catalan provide healthy omega fats

These salads pack omega-3s and good taste into healthy summer packages.

 

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Stay tuned for more special offers and resources!

To ensure you receive all special offers from Ray & Terry's, please add info@rayandterry.com to your address book or contacts list.

Best wishes for great health!
Ray & Terry's Longevity Products
Ray Kurzweil and Terry Grossman, M.D.

 
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What About Vegetarians?

Flaxseeds and Algae

There are several key nutrients that are not plentiful in a vegetarian diet. New research indicates that vegetarians, and especially vegans, have an increased risk of heart disease because of a dietary tendency to inadequate intake of omega-3 and vitamin B12. 

Omega-3 are best taken as fish oil, because of the high concentration of EPA and DHA found naturally in fish oil derived from cold water fish. But fish is not for everyone, so what’s the solution?

Flax seed is a good vegetarian source of DHA, but it does not contain EPA. The balance between these two fatty acids is important.

Algae sources are the best balanced option for vegetarians and vegans. In fact, fish get their omega-3 levels because of the algae they consume. Algae are also a more sustainable source with lower levels of contaminants.

D. Li. "Chemistry behind Vegetarianism." Journal of Agricultural and Food Chemistry. Vol 59 (3):777–784. 2011.

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News & Notes

Sugar causes brain damage, but omega-3s appear to counteract the damage.

"The new rat study from UCLA is the first to show how a diet high in fructose slows the brain, hampering memory and learning … and that omega-3 DHA can counteract the disruption (Agrawal R, Gomez-Pinilla F 2012)."

Anti-Brain-Shrinkage: A recent study is one of the first to measure blood levels of nutrients, including omega-3s, vitamins B, C, D, E and their relationship to cognitive health and brain volume. The researchers linked better cognitive skills and less brain shrinkage to higher blood levels of key nutrients, and the opposite results to lower blood levels.

Proven again: the heart is healthier with a diet including plenty of fish, legumes and healthy fats. This NYC study was less focused on Europeans and Mediterranean diet than some previous studies.

Mercury and Selenium
Did you know that fish also contains selenium, which contributes to the bigger picture of mercury toxicity? Avoiding species with high mercury levels is one step you should take. But selenium also has a mechanism of binding to mercury and preventing absorption in the body.

How do EPA and DHA protect the heart?

The answer has been elusive. The omega-3 fatty acids exert an anti-inflammatory effect, but the mechanism has not been clear.

This study mapped the cellular process occurring after EPA supplementation and found that the nutrient blocks the cyclooxygenase enzyme (COX), which is a precursor to inflammation. COX produces hormones called prostaglandins, which cause inflammation in the body. This is similar to the mechanism of aspirin, which blocks COX-2 signaling, thereby reducing inflammation and pain.

 

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Videos

High Energy Power Bars
High Energy Power Bars: This recipe using hemp seeds and flax seeds is easy, quick, and contains fiber and healthy omega-3s.


Men who don’t get enough omega-3 fatty acids face increased risk of cardiovascular and neurological problems.


JAMA report on the link between fish oil levels and telomeres.


Quick report on omega-3 and memory loss


Healthy fish recipes without the charring: Fish on the Barbeque 101

 
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Qualified Heath Claim

AnnouncementThe FDA approves this claim:

"Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease."

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Healthy Trivia

TriviaWhich contains more EPA?

a. Flax seed
b. Salmon
c. Lamb
d. Algae

Click here for the answer

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References:

Agrawal R, Gomez-Pinilla F. 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol. 2012 May 15;590(Pt 10):2485-99. Epub 2012 Apr 2. Accessed at http://jp.physoc.org/content/early/2012/03/31/jphysiol.2012.230078.abstrac

Buyken AE, Flood V, Rochtchina E, Nestel P, Brand-Miller J, Mitchell P. Modifications in dietary fat quality are associated with changes in serum lipids of older adults independently of lipid medication. J Nutr. 2010 Jan;140(1):88-94. Epub 2009 Nov 18. PMID: 19923396

Becker DJ, Gordon RY, Morris PB, Yorko J, Gordon YJ, Li M, Iqbal N. Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial. Mayo Clin Proc. 2008 Jul;83(7):758-64. PMID: 18613992

Carpentier YA, Portois L, Malaisse WJ. n-3 fatty acids and the metabolic syndrome. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1499S-1504S. Review.

Chiu CJ, Klein R, Milton RC, Gensler G, Taylor A. "Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?" Br J Ophthalmol. 2009 Sep;93(9):1241-6. Epub 2009 Jun 9. PMID: 19508997

Corsinovi L. et al. "Dietary lipids and their oxidized products in Alzheimer's disease."Mol Nutr Food Res. 2011 Sep;55 Suppl 2:S161-SS172. Epub 2011 Aug 31.

Dyall SC, Michael GJ, Whelpton R, Scott AG, Michael-Titus AT. "Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain." Neurobiol Aging. 2007 Mar;28(3):424-39. Epub 2006 Feb 28. PMID: 16500747

Gammelmark A, Madsen T, Varming K, Lundbye-Christensen S, Schmidt EB. "Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects." Nutr Res. 2012 Jan;32(1):15-23. PMID: 22260859

Hacquebard M, Portois L, Malaisse WJ, *Carpentier YA. "The metabolic syndrome of omega3-depleted rats. IV. Intestinal phospholipid omega3 fatty acids." Int J Mol Med. 2009 Dec;24(6):859-65. PMID: 19885630

J. T. Huang et al. "High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials ." Nutrition.2011. doi: 10.1016/j.nut.2010.12.011

Kiecolt-Glaser, J. Brain, Behavior and Immunity. 2011

Kuriki K, Hirose K, Wakai K, Matsuo K, Ito H, Suzuki T, Hiraki A, Saito T, Iwata H, Tatematsu M, Tajima K. Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer. 2007 Jul 15;121(2):377-85. PMID: 17354239

L. Knott, N.C. Avery, A.P. Hollander, J.F. Tarlton. "Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease." Osteoarthritis and Cartilage, Volume 19, Issue 9, September 2011. PMID: 21723952

Lalancette-Hébert M, Julien C, Cordeau P, Bohacek I, Weng YC, Calon F, Kriz J. "Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage." Stroke. 2011 Oct;42(10):2903-9. Epub 2011 Aug 18. PMID: 21852616

Lespérance F, et al. "The efficacy of omega-3 supplementation for major depression: a randomized controlled trial." J Clin Psychiatry. 2011 Aug;72(8):1054-62. Epub 2010 Jun 15. PMID: 20584525

Norris PC, Dennis EA. "Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling." Proc Natl Acad Sci U S A. 2012 May 14. [Epub ahead of print] PMID: 22586114

SanGiovanni JP, et al. "The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20."Arch Ophthalmol. 2007 May;125(5):671-9. PMID: 17502507

Sapieha P, et al. "5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of {omega}-3 Polyunsaturated Fatty Acids." Sci Transl Med. 2011 Feb 9;3(69):69ra12.

Seddon JM, Cote J, Rosner B. "Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake."Arch Ophthalmol. 2003 Dec;121(12):1728-37. PMID: 14662593

Siasos G. Int J Cardiol. 2011 Nov 17. [Epub ahead of print]

Strøm M, Halldorsson TI, Mortensen EL, Torp-Pedersen C, Olsen SF. "Fish, n-3 fatty acids, and cardiovascular diseases in women of reproductive age: a prospective study in a large national cohort." Hypertension. 2012 Jan;59(1):36-43. Epub 2011 Dec 5. PMID: 22146511

University of Pittsburgh School of Medicine (UPMC). Eating Fish Reduces Risk of Alzheimer’s Disease, Pitt Study Finds. Nov. 30, 2011. Accessed at http://www.upmc.com/MediaRelations/NewsReleases/2011/Pages/Eating-Fish-Reduces-Risk-Alzheimers.aspx

 
0 Comments | Posted in Research Digest By Sarah Brangan

09-20-2012 Heart Disease

Thursday, September 20, 2012 1:18:58 PM America/New_York

Ray and Terry's Logo Thank you for your dedication and work. Your work and advice will assist me as I endeavor to live long enough to reap the benefits the scientific community offers mankind's future. -Donald, Moweaqua, IL
New Research Digest: Heart Disease
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Dear Valued Customer,

Time for the 3rd quarterly edition of our Research Digest series. This special research digest edition focuses on studies and stories about heart disease.

Heart disease is still the leading cause of death in the United States and Canada, affecting one in three people.

Cardiovascular disease is also a major global cause of disability.

Statistics

Click to see high resolution heart disease death rate chart

» Worldwide

Cardiovascular diseases (CVD) kill more people than any other cause in the world. The death rate is approximately 1 in 3 from CVD.

More than 80% of heart disease occurrences are caused by lifestyle.

Roughly half of all deaths from stroke and heart disease are caused by elevated blood pressure. The World Health Organization (WHO) reported that one in three adults worldwide, and almost half the adult population in some countries, have this condition.

» United States

According to the American Heart Association (AHA, 2011 report):

At least 1 in 3 American adults have

Over 2200 Americans die of CVD each day, an average of 1 death every 39 seconds.

More women die of heart disease than all forms of cancer combined.

Nearly 33% of deaths due to CVD occur well before the average life expectancy.

The death rate from CVD (cardiovascular disease) has declined slightly in the past decades. However, disease rates are still high and risk factors due to lifestyle remain prevalent amongst nearly all populations.

Risky Business

One third of American adults have high blood pressure

Diabetes and prediabetes affect close to half the population

Roughly one in five Americans smokes cigarettes

About 15% of the US population has elevated cholesterol

View the full AHA report

 

Risk & Recourse

The AHA names these major risk factors: high cholesterol, high blood pressure, smoking, diabetes.

The WHO lists these major causes: tobacco use, physical inactivity, unhealthy diet, harmful use of alcohol.

Together, lifestyle factors account for 80% of CVD cases. This boils down fast:

1

Eating habits

2

Activity level

3

Smoking habits

4

Stress management

lifestyles

» Lifestyle, Lifestyle, Lifestyle

Repeated study finds that lifestyle management can significantly reduce the risk of heart disease. In one large study of women, lifestyle reduced their risk by as much as 83%, when combining healthy factors.

This particular study measured smoking, alcohol consumption, exercise levels, BMI, and good nutrition.

Heart Disease and Stroke Statistics--2011 Update : A Report From the American Heart Association(page 24). Circulation. 2011;123:e18-e209; originally published online December 15, 2010.

Even with a higher genetic risk, good lifestyle choices reduce the risk of heart disease by about half. A new study found that “among men with a parental history of premature heart attack, those with a healthier lifestyle were less likely to develop heart failure over two decades.”

The good news is that a few lifestyle changes can reduce all of your risk factors.

* Attention to nutrition will reduce your weight, blood pressure and cholesterol levels.

* Exercise helps maintain cardio fitness, plus alleviates stress and reduces blood pressure. Physical activity can reduce the risk of heart disease by as much as 15%.

* Don’t smoke.

* Make time to manage stress. You don’t have to meditate, if that isn’t your thing. Play with a pet, talk with friends, listen to music, or just sit quietly. Figure out what calms you and allow yourself the time.

These small changes make a big difference.

For free access to Ray & Terry’s chapter of Transcend entitled “How to Keep Your Heart Beating”

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Stay tuned for more special offers and resources!

To ensure you receive all special offers from Ray & Terry's, please add info@rayandterry.com to your address book or contacts list.

Best wishes for great health!
Ray & Terry's Longevity Products
Ray Kurzweil and Terry Grossman, M.D.

 
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Advances

‘Clot nets’
Using small nets to fish blood clots out from inside people's brains may be the future of stroke care, according to a pair of studies.

Kidney Numbing for Blood Pressure
A device approved in Europe deadens the nerves in the kidneys in order to help lower blood pressure. There is word that some doctors are impressed with this approach, which can help individuals with elevated blood pressure that does not respond well to medication.

Options for Blood Clotting
New medication options exist to manage blood clot risk. There are side effects to these medications, but the drugs provide useful alternatives (to warfarin and Coumadin) for certain patients. Talk to your doctor for more information.

New Blood Salvage Technology
Open-heart surgery results in a lot of wasted blood and therefore uses a lot of donor blood. A new technology designed to salvage surgical blood would recycle the patient’s own blood and improve transfusions, as well as reduce the deficit of donor supplied blood.

Apps & Gadgets

What is your target heart rate? Check it with this quick tool.

» Heart Disease Risk Questionnaire

Take a few minutes to evaluate your personal risk of heart disease. This free tool comes to you from the Siteman Cancer Center and will take less than 5 minutes.

» Touchless heart rate monitor

There are several iPhone apps to measure heart rate by placing a finger over the camera lens. New apps strive to measure just by observing your face. And they appear to be fairly accurate.

» Stethoscope attachment for smartphone

The StethoCloud app guides the user through the proper method for listening to a patient’s breathing when the “stethomic” attachment – a small microphone that plugs into the smartphone’s audio input. This app was created to help fight pneumonia, the world’s leading cause of death in children.

 

Food

Nutrition is essential to help your heart stay healthy. Include lots of vegetables and whole grains, while minimizing oils and saturated fats. Try eating vegetarian meals at least once a week to broaden your heart-healthy horizons.

Protect your heart with the foods from this beautiful slideshow  

'Meaty' Black Bean Tacos with Corn Salsa. This recipe is low in saturated fat and high in fiber, plus it contains whole grains, vegetables, and lots of flavor.

Fish recipes typically have fewer calories and a healthier fat balance. Try this Mediterranean Baked Cod recipe from Ray & Terry’s own kitchen.

Meatless Monday is an excellent source of vegetarian recipes.

 

Videos

VIDEO -  Basic Anatomy of Your Cardiovascular System
The basic anatomy of your cardiovascular system

VIDEO - Belly Fat and Heart Disease
Not just vanity—belly fat and heart disease

VIDEO - Identify the Symtoms of a Heart Attack
Know how to identify the symptoms of heart attack

VIDEO - Heart Healthy Vegetarian Recipes
Check out easy vegetarian recipes like Indian hummus

 
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Smoking Recovery

AnnouncementSmoking increases your chance of heart attack by 70%... But quitting smoking decreases your chances almost immediately!

20 minutes after quitting smoking, heart rate starts to decrease

Blood pressure drops to nearly normal in 2 hours

Within 24 hours, heart attack risk begins to decline

http://www.gwu.edu

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Healthy Trivia

TriviaWhich of these statements is most true?

a

LDL is ‘bad’ cholesterol, HDL is ‘good’ cholesterol

b

HDL is ‘bad’ cholesterol, LDL is ‘good’ cholesterol

c

All cholesterol is ‘bad’

d

All cholesterol is ‘good’

Click here for the answer

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0 Comments | Posted in Research Digest By Sarah Brangan

04-03-2012 Cancer

Tuesday, April 17, 2012 9:14:17 AM America/New_York

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Dear Valued Customer,

Welcome to the first edition of our new Research Digest. Based on feedback from our readers, we have decided to publish periodic issues devoted entirely to health-related research updates and news items.

Cancer riibbonsThis special research digest edition focuses on studies and stories about cancer.

During 2011, in the US alone, over 1.5 million new cases of cancer were diagnosed and more than 500,000 people died from its various forms.

Already at over $280 billion a year, the cost of cancer (new treatments, new cases) is ballooning and expected to increase as new diagnoses are predicted to double in the next fifteen years.

Scientists all over the world, including our own Ray Kurzweil, are working hard to understand and fight the processes that fuel cancer.

 

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Research Studies

Micronutrients influence DNA repair - usually enhancing activity and can help prevent cancer. DNA repair is an essential cellular function, which, by removing DNA damage before it can cause mutations, contributes crucially to the prevention of cancer.

Spotlight

Beware of Mammograms

Ray & Terry recommend breast cancer screening in women under 40, but not necessarily mammograms. Have you ever heard of thermography? Using heat, thermograms can help detect tumor presence without squishing or radiation.

A little information on the risks of mammograms

For early detection and no harm to the body, learn about thermograms

"After 10 years of annual screening, more than half of women will receive at least 1 false-positive recall, and 7% to 9% will receive a false-positive biopsy recommendation." Hubbard et al. Ann Intern Med. October 18, 2011 vol. 155 no. 8 481-492

The best prevention is a combination of methods, including regular self- and medical- exams. You are your own best advocate.

Metabolizing red meat and dairy in the human body can result in an accumulation of a particular molecule called Neu5Gc, according to this study. The accumulation contributes to chronic inflammation, which contributes to cancer risk.

Dietary soluble fiber intake is associated with a significantly reduced risk of ER− breast cancer among pre-menopausal women. Additional studies with larger sample size are needed to confirm these results.

Compelling evidence of the link between prostate cancer and insulin-like growth factor 1 (IGF-1). In this study, researchers discovered that the growth hormone may inhibit "programmed cell death." This can lead to cells reproducing abnormally as they do with cancer.

3-D picture of cancer prevention cells were revealed, according to research published in Nature Structural & Molecular Biology.

Potential biomarkers for melanoma and other inflammatory cancers were identified in a recent study, paving the way for better prevention. These researchers developed a potential new method for the diagnosis, prognosis, and monitoring of inflammatory cancers.

Tumors examined in a laboratory were more complex than previously recognized, suggesting that personalized-medicine strategies based on a single biopsy underestimate cancer's ability to evolve, adapt, and resist treatment, investigators said.

Dietary fiber is associated with reduced risk of colorectal cancer. Colorectal cancer is the third most common type of cancer worldwide. This review of pertinent studies concluded that the link exists.

Vitamin D may be a helpful nutrient in the prevention of cancer and maintenance of healthy cell division. For specific study references and abstracts, see this list.

Lower risk of colorectal cancer has been linked to higher levels of vitamin D in the blood. The largest study ever conducted on the topic confirmed this link in both men and women.

 

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Foods

Watercress is a cruciferous vegetable that also contains lots of chlorophyll and iodine. Unless you have hyperthyroidism, try including this healthy green in sandwiches and salads. It offers antioxidants and oxygen for the cells (which hurts cancer cells).

Kale provides comprehensive support for the body's detoxification system. It also protects against 5 kinds of cancer and works to lower cholesterol, fight inflammation and combat oxidation.

Include kale when you juice vegetables, or try this quick and easy kale soup

Brussel sprouts

Brussels sprouts are delicious. They also offer cancer-preventive components in a special combination and may have unique health benefits in the area of DNA protection. One small study showed improved stability of DNA inside human white blood cells after daily consumption of Brussels sprouts.

Try them roasted, sautéed or steamed with some simple dressing ingredients like lemon and garlic.

Ginger reduced colon inflammation by 28% in a recent study. Minimize inflammation to minimize cancer risk. Supplements can allow consumption of more concentrated and effective amounts than diet alone.

Garlic has amazing power per ounce. Its unique compounds promote antioxidant activity and function as powerful antibacterial and antiviral agents. It contains allicin, which helps reduce blood pressure and decrease LDL cholesterol, plus works with vitamin C to protect against colon cancer.

Whey protein has been studied for its potential anti-cancer effects. The results of this study "strongly suggest an anti-tumor effect of a whey protein dietary supplement [in certain cancers]"

 

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Stay tuned for more special offers and resources!

To ensure you receive all special offers from Ray & Terry's, please add info@rayandterry.com to your address book or contacts list.

Best wishes for great health!
Ray & Terry's Longevity Products
Ray Kurzweil and Terry Grossman, M.D.

 
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Statistics

Worldwide

Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world.

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths.

Good News - EU reports a steady decline in cancer death rates

US cancer statistics and graphs

The American Cancer Society 2011 Report provides the estimated numbers of new cancer cases and deaths in 2011 as well as cancer incidence, mortality, and survival statistics and information on cancer symptoms, risk factors, early detection, and treatment. The topic of the special section is cancer disparities and avoidable premature cancer deaths.

 

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KurzweilAI Reports

Laser-induced ultrasound can detect melanoma long before tumors form.

3D cellular imaging for breast cancer detection

Mining for cancer

DNA origami used to promote suicide of cancer cells

Using a Trojan Horse to fight cancer.

Understanding cellular signals to address cancer cell proliferation

Cooking tumors from the inside

 

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Videos


Lance Armstrong
talks about his cancer and how to be your own advocate.


Shrinking tumors and killing cancer cells. New cutting edge treatments


Interesting exploration regarding cancer cells from the SENS 5 Foundation conference, forwarded by one of our readers. (not a high-quality recording; involves some scientific discussion.)


Vitamin D and its potential use against cancer, particularly breast cancer.

 
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Rulings

AnnouncementIn a 2011 court case, Vitamin C and Vitamin E won the right to state the following:

"Vitamin C may reduce the risk of gastric cancer."

"Vitamin E may reduce the risk of bladder cancer."

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emailKnow someone who might be interested in this email? Forward it to them.

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Healthy Trivia

TriviaWhich of these foods contains the most calcium per calorie plus helps fight cancer?

a. 1 cup 2% milk
b. 1 cup collard greens
c. 2 ounces of cheese
d. 1 cup green peas

Click here for the answer

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1 Comments | Posted in Research Digest By Sarah Brangan